Once serotonin is made, it may need more support to pass into the synapse and travel to and bind to the serotonin receptors. MAOA and MAOB enzymes can degrade the serotonin. This is more common in people that have “fast” MAOA and MAOB activity due to genetic differences. The serotonin can also be “reuptaked” by a solute carrier known as a reuptake protein. If MAOA and MAOB enzymes are active, and serotonin is passing back through reuptake proteins, very little serotonin makes it to the receptors that give us feelings of normal happiness and calm.^† The herb Saffron has been used throughout history to support a healthy mood. Science is now explaining some of the functions of the chemicals found in saffron. Dr. Lynch included the patented Safr’Inside™ ingredient in Serotonin Nutrients because it appears to both slow MAOA and MAOB as well as slow the reuptake of serotonin by inhibiting the activity of SLC6A4 gene. This gene is responsible for making the reuptake proteins that pull more serotonin out of the synapse before they reach the desired receptors. As a result, this saffron derived ingredient supports healthy serotonin levels traveling to the serotonin receptors.^† After attaching to the receptors, the serotonin initiates a signaling process that relies on inositol to carry out its function. Serotonin Nutrients includes this important ingredient to make sure the support for serotonin begins at the beginning and ends at the end.^† When we are lacking adequate serotonin and have a poor mood, we will often find that we crave foods and behaviors to bring us a boost. This may lead to an increase in consumption of sweets and other additive foods and behaviors. Serotonin Nutrients may support healthy food and behavior choices by supporting normal healthy serotonin levels.^† Serotonin is a complete serotonin and mood support supplement containing the additional cofactors of multiple pathways to ensure a healthy pathway balance.^†